Olivier Rascol Selected Research

opicapone

9/2022	Opicapone as an Add-on to Levodopa in Patients with Parkinson's Disease Without Motor Fluctuations: Rationale and Design of the Phase III, Double-Blind, Randomised, Placebo-Controlled EPSILON Trial.
3/2022	Opicapone versus placebo in the treatment of Parkinson's disease patients with end-of-dose motor fluctuation-associated pain: rationale and design of the randomised, double-blind OCEAN (OpiCapone Effect on motor fluctuations and pAiN) trial.
1/2021	Opicapone for Parkinson's disease: clinical evidence and future perspectives.
1/2021	The Added Benefit of Opicapone When Used Early in Parkinson's Disease Patients With Levodopa-Induced Motor Fluctuations: A Post-hoc Analysis of BIPARK-I and -II.
1/2021	Redefining the strategy for the use of COMT inhibitors in Parkinson's disease: the role of opicapone.
1/2019	Safety Profile of Opicapone in the Management of Parkinson's Disease.
10/2018	Opicapone for the treatment of Parkinson's disease: A review of a new licensed medicine.
1/2018	Effectiveness of opicapone and switching from entacapone in fluctuating Parkinson disease.
7/2017	Opicapone for the management of end-of-dose motor fluctuations in patients with Parkinson's disease treated with L-DOPA.
2/2017	Opicapone as Adjunct to Levodopa Therapy in Patients With Parkinson Disease and Motor Fluctuations: A Randomized Clinical Trial.

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Olivier Rascol Research Topics

Disease

136	Parkinson Disease (Parkinson's Disease) 09/2022 - 01/2003
46	Dyskinesias (Dyskinesia) 01/2022 - 01/2003
15	Multiple System Atrophy 01/2022 - 08/2003
11	Pain (Aches) 03/2022 - 01/2003
11	Orthostatic Hypotension (Postural Hypotension) 01/2022 - 07/2011
10	Parkinsonian Disorders (Parkinsonism) 12/2021 - 05/2005
9	Fatigue 01/2021 - 05/2010
9	Nausea 12/2020 - 04/2010
8	Constipation 01/2019 - 11/2010
8	Disease Progression 11/2016 - 05/2005
8	Sleepiness 01/2016 - 08/2006
7	Disruptive, Impulse Control, and Conduct Disorders (Kleptomania) 01/2021 - 09/2010
7	Hallucinations (Hallucination) 01/2020 - 12/2009
6	Dementia (Dementias) 11/2019 - 10/2005
6	Dizziness (Lightheadedness) 04/2019 - 04/2010
6	Drug-Related Side Effects and Adverse Reactions 09/2018 - 05/2008
5	Movement Disorders (Movement Disorder) 12/2021 - 03/2013
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 07/2014
5	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2019 - 10/2005
4	Disorders of Excessive Somnolence (Hypersomnia) 01/2016 - 01/2006
4	Psychotic Disorders (Schizoaffective Disorder) 10/2015 - 01/2003
4	Autonomic Nervous System Diseases (Dysautonomia) 11/2010 - 08/2003
3	Synucleinopathies 01/2022 - 07/2014
3	Tardive Dyskinesia 12/2021 - 02/2007
3	Atrophy 01/2018 - 08/2009
3	Tremor (Tremors) 11/2016 - 10/2005
3	Restless Legs Syndrome (Restless Legs) 11/2016 - 12/2012
3	Neuralgia (Stump Neuralgia) 05/2013 - 06/2012
3	Sialorrhea 03/2013 - 01/2011
3	Hypokinesia (Bradykinesia) 07/2012 - 10/2005
2	Encephalitis (Encephalitis, Rasmussen) 01/2019 - 01/2019
2	Cognitive Dysfunction 01/2019 - 01/2003
2	Edema (Dropsy) 01/2018 - 10/2015
2	Confusion (Bewilderment) 01/2018 - 09/2010
2	Heart Failure 01/2017 - 03/2014
2	Chronic Pain 01/2016 - 07/2008
2	Hypotension (Low Blood Pressure) 03/2015 - 09/2010
2	Erectile Dysfunction 03/2013 - 10/2011
2	Dystonia (Limb Dystonia) 06/2012 - 08/2003

Drug/Important Bio-Agent (IBA)

78	Levodopa (L Dopa)FDA LinkGeneric 09/2022 - 01/2003
18	Pharmaceutical PreparationsIBA 01/2022 - 01/2003
18	Dopamine Agonists (Dopamine Agonist)IBA 12/2018 - 07/2003
16	Pramipexole (Mirapex)FDA LinkGeneric 03/2014 - 06/2007
11	opicaponeIBA 09/2022 - 01/2016
11	Dopamine (Intropin)FDA LinkGeneric 11/2018 - 07/2003
10	Amantadine (Aman)FDA LinkGeneric 01/2022 - 05/2011
10	rasagiline (Azilect)FDA Link 10/2016 - 05/2005
7	Dopamine Agents (Dopaminergic Agents)IBA 12/2020 - 01/2006
7	entacapone (Comtan)FDA Link 01/2018 - 09/2004
7	Pergolide (Permax)FDA Link 01/2017 - 05/2005
7	ropinirole (Requip)FDA LinkGeneric 10/2011 - 07/2003
6	SynucleinsIBA 01/2021 - 11/2019
6	Antipsychotic Agents (Antipsychotics)IBA 09/2017 - 02/2007
5	Apomorphine FDA Link 01/2021 - 09/2004
5	rotigotine FDA Link 01/2016 - 06/2007
4	hydroxide ionIBA 01/2022 - 06/2012
4	IronIBA 01/2018 - 08/2009
4	Cabergoline FDA LinkGeneric 01/2017 - 12/2009
4	Piribedil (Trivastal)IBA 01/2016 - 04/2003
4	Methylphenidate (Ritalin)FDA LinkGeneric 05/2015 - 11/2006
4	Carbidopa (Lodosyn)FDA LinkGeneric 07/2013 - 07/2010
3	catechol (pyrocatechol)IBA 01/2022 - 09/2004
3	TransferasesIBA 01/2022 - 09/2004
3	Serotonin (5 Hydroxytryptamine)IBA 01/2021 - 01/2002
3	2- (2- furanyl)- 7- (2- (4- (4- (2- methoxyethoxy)phenyl)- 1- piperazinyl)ethyl)- 7H- pyrazolo(4,3- e)(1,2,4)triazolo(1,5- c)pyrimidine- 5- amineIBA 11/2020 - 12/2015
3	Adenosine (Adenocard)FDA LinkGeneric 11/2020 - 12/2015
3	Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA 01/2019 - 12/2010
3	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 01/2016 - 07/2014
3	6- fluoro- 2- (4- (pyridin- 2- yl)but- 3- yn- 1- yl)imidazo(1,2- a)pyridineIBA 01/2016 - 07/2014
3	Analgesics (Analgesic Drugs)IBA 12/2015 - 07/2008
3	Antidepressive Agents (Antidepressants)IBA 12/2012 - 06/2010
3	perampanelIBA 02/2012 - 05/2010
3	sarizotanIBA 04/2008 - 03/2004
2	istradefyllineIBA 01/2021 - 11/2020
2	Fluoxetine (Prozac)FDA LinkGeneric 01/2021 - 10/2011
2	Domperidone (Domperidon)IBA 12/2020 - 10/2011
2	Delayed-Action PreparationsIBA 01/2020 - 09/2015
2	Leucine (L-Leucine)FDA Link 01/2020 - 01/2019
2	DroxidopaIBA 04/2019 - 03/2015
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 04/2019 - 07/2012
2	Biomarkers (Surrogate Marker)IBA 01/2019 - 07/2014
2	naftazoneIBA 01/2019 - 08/2012
2	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2019 - 05/2015
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2016 - 07/2014
2	Oxycodone (Oxycontin)FDA LinkGeneric 12/2015 - 06/2012
2	Naloxone (Narcan)FDA LinkGeneric 12/2015 - 06/2012
2	mavoglurantIBA 09/2014 - 11/2013
2	amsonic acid (DAS)IBA 03/2014 - 09/2010
2	Pain-FreeIBA 05/2013 - 11/2012
2	Glycopyrrolate (Glycopyrronium Bromide)FDA LinkGeneric 03/2013 - 10/2011
2	Sildenafil Citrate (Viagra)FDA Link 03/2013 - 10/2011
2	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 03/2013 - 10/2011
2	Botulinum Toxins (Botulinum Toxin)IBA 03/2013 - 06/2012
2	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 06/2012 - 10/2011

Therapy/Procedure

40	Therapeutics 03/2022 - 01/2003
8	Deep Brain Stimulation 01/2022 - 02/2007
7	Activities of Daily Living (ADL) 11/2021 - 12/2007
2	Drug Therapy (Chemotherapy) 01/2022 - 10/2005
2	Immunotherapy 01/2021 - 11/2020
2	Transdermal Patch 01/2016 - 02/2013